Regulation of membrane repolarization during ventricular cardiac muscle cell action potential

Across TCGA patient cohorts, RNA activity of the Regulation of membrane repolarization during ventricular cardiac muscle cell action potential pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RPLP1P6, MTMR8, and TVP23BP2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of membrane repolarization during ventricular cardiac muscle cell action potential activity versus RPLP1P6 in CCRCC (Pearson r = 0.18).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	RPLP1P6 →	+0.681	+0.305	.004	.005	3	4
HNSC	MTMR8 →	-0.751	-0.223	.005	.002	3	2
UCEC	TVP23BP2 →	-0.865	-0.706	<.001	.002	3	2
HNSC	PCDHB2 →	-0.734	-0.129	.006	.008	3	2
HNSC	STAC2 →	-0.299	-0.204	.005	.001	3	2
HNSC	OR3A4P →	-0.089	-0.170	.003	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1905024 vs RPLP1P6 — CCRCC

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