Regulation of epithelial to mesenchymal transition involved in endocardial cushion formation

Across TCGA cell cohorts, RNA activity of the Regulation of epithelial to mesenchymal transition involved in endocardial cushion formation pathway is significantly associated with the shRNA dependency of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TEAD1, COX4I1, and MED12, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TEAD1 grouped by Regulation of epithelial to mesenchymal transition involved in endocardial cushion formation-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	TEAD1 →	+0.986	+0.294	<.001	.001	3	6
LUNG_NSCLC_LUAD	COX4I1 →	-0.238	-0.670	.001	.002	3	5
CNS	MED12 →	-0.344	-0.190	.003	.001	2	5
CNS	PCDHGC5 →	+0.258	+0.210	.002	.002	3	3
OESOPHAGUS	SERINC3 →	-0.202	-0.217	<.001	.002	3	3
BLOOD_Leukemia	WFDC5 →	-0.136	-0.163	.006	.004	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TEAD1 by Regulation of epithelial to mesenchymal transition involved in endocardial cushion formation activity — LIVER

Explore this box plot interactively →