Regulation of epithelial to mesenchymal transition involved in endocardial cushion formation

Across TCGA cell cohorts, RNA activity of the Regulation of epithelial to mesenchymal transition involved in endocardial cushion formation pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SPATA5, SERPINB6, and CDKAL1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SPATA5 grouped by Regulation of epithelial to mesenchymal transition involved in endocardial cushion formation-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	SPATA5 →	+0.360	+2.318	.004	.002	2	3
SKIN	SERPINB6 →	-0.390	-2.080	.008	<.001	3	2
BREAST	CDKAL1 →	-0.380	-1.761	.001	<.001	3	2
LUNG_NSCLC_LUAD	ZKSCAN8 →	-0.170	-2.318	.008	.002	2	2
LUNG_NSCLC_LUAD	LY6K →	+0.265	+2.318	.004	.002	2	2
LUNG_NSCLC_LUAD	NSD1 →	+0.375	+2.140	.002	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SPATA5 by Regulation of epithelial to mesenchymal transition involved in endocardial cushion formation activity — LUNG_NSCLC_LUAD

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