Regulation of leukocyte adhesion to arterial endothelial cell

Across TCGA patient cohorts, RNA activity of the Regulation of leukocyte adhesion to arterial endothelial cell pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MICAL1, PLEKHO2, and TBC1D2B_T277, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of leukocyte adhesion to arterial endothelial cell activity versus MICAL1 in OV (Pearson r = 0.33).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	MICAL1 →	+0.327	+0.057	.005	.009	3	7
GBM	PLEKHO2 →	+0.259	+0.084	<.001	<.001	3	7
GBM	TBC1D2B_T277 →	+0.422	+0.104	<.001	<.001	3	6
GBM	GIMAP7 →	+0.519	+0.089	<.001	<.001	3	6
HNSC	FNBP1 →	+0.328	+0.055	<.001	.004	3	6
GBM	FMNL1 →	+0.440	+0.097	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904997 vs MICAL1 — OV

Explore this scatter interactively →