Regulation of leukocyte adhesion to arterial endothelial cell

Across TCGA patient cohorts, RNA activity of the Regulation of leukocyte adhesion to arterial endothelial cell pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are OVOL1, IL36RN, and GRHL3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of leukocyte adhesion to arterial endothelial cell activity versus OVOL1 in HNSC (Pearson r = 0.29).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	OVOL1 →	+0.938	+0.301	.005	.005	3	5
LSCC	IL36RN →	+1.352	+0.573	.002	.001	3	4
LSCC	GRHL3 →	+1.442	+0.446	<.001	.006	3	4
LSCC	JAM3 →	-0.513	-0.438	<.001	<.001	3	4
HNSC	CNFN →	+1.938	+0.407	<.001	.005	3	3
LSCC	ARMC2 →	-0.390	-0.560	.008	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904997 vs OVOL1 — HNSC

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