Regulation of leukocyte adhesion to arterial endothelial cell

Across TCGA cell cohorts, RNA activity of the Regulation of leukocyte adhesion to arterial endothelial cell pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PRKAR1A, TNFRSF11B, and BOLA3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PRKAR1A grouped by Regulation of leukocyte adhesion to arterial endothelial cell-low versus -high activity in BLOOD_Lymphoma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	PRKAR1A →	-1.330	-1.956	<.001	.006	2	5
LIVER	TNFRSF11B →	+5.109	+1.812	<.001	<.001	3	4
LUNG_NSCLC_LUSC	BOLA3 →	+0.499	+1.278	.006	.004	3	4
PANCREAS	NNMT →	+3.461	+1.170	.001	.003	3	3
BLOOD_Myeloma	ZNF74 →	-1.196	-1.715	.006	.002	3	3
BLOOD_Lymphoma	GNPTAB →	+1.323	+2.191	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PRKAR1A by Regulation of leukocyte adhesion to arterial endothelial cell activity — BLOOD_Lymphoma

Explore this box plot interactively →