Positive regulation of leukocyte adhesion to vascular endothelial cell

Across TCGA patient cohorts, RNA activity of the Positive regulation of leukocyte adhesion to vascular endothelial cell pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FBXO21, TMEM9, and TOMM20, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of leukocyte adhesion to vascular endothelial cell activity versus FBXO21 in LUAD (Pearson r = -0.29).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	FBXO21 →	-0.473	-0.379	<.001	<.001	3	6
LUAD	TMEM9 →	-0.510	-0.341	<.001	.003	3	6
CCRCC	TOMM20 →	-0.287	-0.227	.006	.002	3	5
HNSC	EPCAM →	-1.513	-0.437	<.001	.006	3	5
LSCC	CPSF3 →	-0.411	-0.294	<.001	.003	3	5
UCEC	SNRPE →	-0.778	-0.808	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904996 vs FBXO21 — LUAD

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