Negative regulation of leukocyte adhesion to vascular endothelial cell

Across TCGA patient cohorts, RNA activity of the Negative regulation of leukocyte adhesion to vascular endothelial cell pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are VWF, ADH1B, and CPA3, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of leukocyte adhesion to vascular endothelial cell activity versus VWF in BRCA (Pearson r = 0.46).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	VWF →	+0.472	+0.105	<.001	.001	3	6
BRCA	ADH1B →	+1.154	+0.109	<.001	<.001	3	6
BRCA	CPA3 →	+0.913	+0.087	<.001	<.001	3	6
BRCA	EHD2 →	+0.570	+0.091	<.001	<.001	3	6
UCEC	EHD2_S438 →	+1.080	+0.122	<.001	<.001	3	6
UCEC	KCTD12 →	+0.479	+0.101	<.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904995 vs VWF — BRCA

Explore this scatter interactively →