Negative regulation of leukocyte adhesion to vascular endothelial cell

Across TCGA patient cohorts, RNA activity of the Negative regulation of leukocyte adhesion to vascular endothelial cell pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IGFBP6, CCL21, and KLF4, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of leukocyte adhesion to vascular endothelial cell activity versus IGFBP6 in BRCA (Pearson r = 0.38).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	IGFBP6 →	+1.434	+0.611	<.001	<.001	3	5
BRCA	CCL21 →	+2.201	+0.606	<.001	<.001	3	4
LSCC	KLF4 →	+0.907	+1.088	<.001	<.001	3	4
BRCA	MYL9 →	+0.969	+0.658	.002	<.001	3	3
BRCA	SRPX →	+0.865	+0.393	<.001	.001	3	3
BRCA	NEK2 →	-0.895	-0.458	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904995 vs IGFBP6 — BRCA

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