Negative regulation of leukocyte adhesion to vascular endothelial cell

Across TCGA cell cohorts, RNA activity of the Negative regulation of leukocyte adhesion to vascular endothelial cell pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KLF4, CCL28, and CCL25, each associated with the pathway in up to 16 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, KLF4 grouped by Negative regulation of leukocyte adhesion to vascular endothelial cell-low versus -high activity in BLOOD_Lymphoma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	KLF4 →	-0.790	-2.460	.002	<.001	2	16
PANCREAS	CCL28 →	-0.466	-2.267	.002	<.001	3	6
BREAST	CCL25 →	-0.370	-0.793	<.001	.001	3	5
SKIN	SLC6A19 →	+0.238	+0.806	<.001	.005	3	5
CNS	RHOU →	+0.224	+0.835	<.001	<.001	3	5
BLOOD_Myeloma	RSC1A1 →	+0.282	+1.484	.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

KLF4 by Negative regulation of leukocyte adhesion to vascular endothelial cell activity — BLOOD_Lymphoma

Explore this box plot interactively →