Negative regulation of leukocyte adhesion to vascular endothelial cell

Across TCGA cell cohorts, RNA activity of the Negative regulation of leukocyte adhesion to vascular endothelial cell pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EPB41L5, PEX1, and ZNF554, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, EPB41L5 grouped by Negative regulation of leukocyte adhesion to vascular endothelial cell-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	EPB41L5 →	-1.238	-0.996	.005	.009	3	3
OVARY	PEX1 →	-0.882	-0.644	.001	.007	3	3
LARGE_INTESTINE	ZNF554 →	-1.081	-1.295	.004	.007	3	3
LARGE_INTESTINE	PLA2G6 →	-1.142	-1.234	<.001	.002	2	4
BREAST	SLC16A3 →	+1.790	+0.565	.004	.003	3	3
CNS	NIPSNAP1 →	-1.083	-1.000	.001	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

EPB41L5 by Negative regulation of leukocyte adhesion to vascular endothelial cell activity — BLOOD_Leukemia

Explore this box plot interactively →