Regulation of leukocyte adhesion to vascular endothelial cell

Across TCGA cell cohorts, RNA activity of the Regulation of leukocyte adhesion to vascular endothelial cell pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GLCCI1, PDCD6IP, and SARS2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GLCCI1 grouped by Regulation of leukocyte adhesion to vascular endothelial cell-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	GLCCI1 →	-0.847	-0.993	.007	<.001	3	5
LIVER	PDCD6IP →	-0.609	-1.031	.008	.004	3	5
KIDNEY	SARS2 →	-0.868	-1.147	.001	.007	3	4
KIDNEY	FAM222B →	-0.817	-1.480	.001	<.001	3	4
LIVER	HSPA13 →	-1.091	-1.366	<.001	<.001	3	4
BLOOD_Lymphoma	HEATR6 →	-2.170	-2.077	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GLCCI1 by Regulation of leukocyte adhesion to vascular endothelial cell activity — PANCREAS

Explore this box plot interactively →