Regulation of endosome organization

Across TCGA patient cohorts, RNA activity of the Regulation of endosome organization pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SAMD9L, TYMP, and ICAM1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of endosome organization activity versus SAMD9L in LSCC (Pearson r = 0.24).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SAMD9L →	+0.655	+0.083	<.001	<.001	3	6
GBM	TYMP →	+0.677	+0.050	.001	<.001	2	7
LSCC	ICAM1 →	+0.741	+0.081	<.001	<.001	3	6
GBM	RASSF5 →	+0.450	+0.054	.003	.001	3	6
LSCC	GMIP →	+0.370	+0.076	<.001	<.001	3	6
UCEC	GPCPD1 →	+0.418	+0.045	.002	.004	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904978 vs SAMD9L — LSCC

Explore this scatter interactively →