Regulation of endosome organization

Across TCGA patient cohorts, RNA activity of the Regulation of endosome organization pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PEX11B, MINCR, and FGR, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of endosome organization activity versus PEX11B in CCRCC (Pearson r = -0.36).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	PEX11B →	-0.278	-0.325	<.001	.004	3	4
GBM	MINCR →	-0.272	-0.166	.008	<.001	2	5
UCEC	FGR →	+0.766	+0.222	.006	.002	3	4
GBM	LHFPL2 →	+0.456	+0.117	<.001	.003	3	4
GBM	LINC00618 →	-0.430	-0.154	.003	<.001	3	4
GBM	SNHG20 →	-0.258	-0.158	.004	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904978 vs PEX11B — CCRCC

Explore this scatter interactively →