Regulation of endosome organization

Across TCGA patient cohorts, RNA activity of the Regulation of endosome organization pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CYFIP1_S583, NFIC_S294, and TOM1_S160, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of endosome organization activity versus CYFIP1_S583 in BRCA (Pearson r = 0.38).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CYFIP1_S583 →	+0.667	+0.087	<.001	<.001	3	4
GBM	NFIC_S294 →	-0.754	-0.203	<.001	<.001	3	3
GBM	TOM1_S160 →	+0.813	+0.265	<.001	<.001	3	3
OV	KDM1B_S247 →	-0.774	-0.723	.002	.005	3	3
LSCC	RAD23A_S133 →	+1.074	+1.644	.001	<.001	3	3
OV	RPRD2_S930 →	-1.110	-0.222	.002	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904978 vs CYFIP1_S583 — BRCA

Explore this scatter interactively →