Regulation of endosome organization

Across TCGA cell cohorts, RNA activity of the Regulation of endosome organization pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TTC9B, CDC37L1, and COTL1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TTC9B grouped by Regulation of endosome organization-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	TTC9B →	+1.293	+1.380	.008	<.001	3	4
KIDNEY	CDC37L1 →	+0.871	+1.347	.004	<.001	3	4
OVARY	COTL1 →	-1.342	-1.190	.005	.001	3	4
LUNG_NSCLC_LUSC	GAB3 →	-0.924	-1.444	.006	<.001	3	4
CNS	MGAT4B →	-0.794	-0.961	.002	.003	3	4
BONE	RASIP1 →	+1.317	+1.695	.009	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TTC9B by Regulation of endosome organization activity — LUNG_SCLC

Explore this box plot interactively →