Negative regulation of establishment of protein localization

Across TCGA cell cohorts, RNA activity of the Negative regulation of establishment of protein localization pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TGM1, MCUB, and RAET1G, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of establishment of protein localization activity versus TGM1 in OESOPHAGUS (Pearson r = -0.63).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	TGM1 →	-2.088	-0.188	.009	.008	3	7
OVARY	MCUB →	+1.290	+0.285	.001	<.001	3	6
BONE	RAET1G →	-1.476	-0.358	.008	.001	2	7
OVARY	ELK1 →	+0.835	+0.228	<.001	.001	3	5
OVARY	ZCCHC7 →	+0.751	+0.216	.007	.009	3	5
OVARY	PBK →	+0.736	+0.163	.007	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904950 vs TGM1 — OESOPHAGUS

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