Interneuron migration

Across TCGA patient cohorts, RNA activity of the Interneuron migration pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SNRK, TK1, and CD34, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Interneuron migration activity versus SNRK in LSCC (Pearson r = -0.01).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SNRK →	+0.209	+0.071	<.001	<.001	3	5
LUAD	TK1 →	-0.517	-0.061	.002	.002	3	4
LSCC	CD34 →	+0.487	+0.075	<.001	.002	3	4
LSCC	DNAJC2 →	-0.327	-0.058	<.001	<.001	3	4
LUAD	GINS4 →	-0.687	-0.065	<.001	.002	3	4
LUAD	MCM2 →	-0.508	-0.060	.004	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904936 vs SNRK — LSCC

Explore this scatter interactively →