ESCRT complex disassembly

Across TCGA patient cohorts, RNA activity of the ESCRT complex disassembly pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are THRAP3_S320, TNS3_S1149, and ME1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, ESCRT complex disassembly activity versus THRAP3_S320 in BRCA (Pearson r = -0.30).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	THRAP3_S320 →	-0.405	-0.040	<.001	.001	3	5
PDAC	TNS3_S1149 →	+0.684	+0.049	<.001	<.001	3	5
OV	ME1 →	+0.403	+0.038	.005	.007	3	5
OV	MICALL2_S712 →	+0.733	+0.039	.001	.002	2	6
PDAC	NAMPT_S472 →	-1.079	-0.053	<.001	<.001	3	5
BRCA	TBCK →	+0.186	+0.044	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904896 vs THRAP3_S320 — BRCA

Explore this scatter interactively →