ESCRT complex disassembly

Across TCGA patient cohorts, RNA activity of the ESCRT complex disassembly pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are C5, ZSWIM7, and PPIAP2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, ESCRT complex disassembly activity versus C5 in GBM (Pearson r = -0.26).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	C5 →	-0.471	-0.076	.002	.001	3	4
LSCC	ZSWIM7 →	-0.258	-0.097	.005	.008	3	4
COAD	PPIAP2 →	-0.194	-0.076	.002	.008	3	3
HNSC	CSNK1G2-AS1 →	+0.431	+0.088	.001	.005	3	3
GBM	RNU4-30P →	+0.825	+0.086	<.001	<.001	3	3
GBM	RAD17P2 →	+0.568	+0.086	.003	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904896 vs C5 — GBM

Explore this scatter interactively →