ESCRT complex disassembly

Across TCGA cell cohorts, RNA activity of the ESCRT complex disassembly pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CARD14, METTL7A, and COX7C, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CARD14 grouped by ESCRT complex disassembly-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	CARD14 →	+2.194	+0.394	<.001	.008	3	5
STOMACH	METTL7A →	-2.613	-0.230	.007	.003	2	5
LARGE_INTESTINE	COX7C →	-0.641	-0.206	.001	.005	3	4
PANCREAS	RPL41 →	-0.624	-0.131	.009	.003	3	4
CNS	USP16 →	+0.564	+0.157	.007	.005	2	5
OESOPHAGUS	IL17C →	+0.308	+0.324	.005	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CARD14 by ESCRT complex disassembly activity — BREAST

Explore this box plot interactively →