Negative regulation of receptor signaling pathway via STAT

Across TCGA patient cohorts, RNA activity of the Negative regulation of receptor signaling pathway via STAT pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KLHDC2, FOSL1, and RGS7BP, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of receptor signaling pathway via STAT activity versus KLHDC2 in GBM (Pearson r = -0.28).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	KLHDC2 →	-0.396	-0.317	<.001	<.001	3	4
PDAC	FOSL1 →	+0.668	+0.112	.001	.009	3	4
PDAC	RGS7BP →	-0.762	-0.138	<.001	.003	3	4
PDAC	SULT2B1 →	+0.607	+0.141	.008	.006	3	4
GBM	DOCK8-AS1 →	+0.416	+0.351	<.001	<.001	3	4
GBM	ICAM1 →	+1.347	+0.410	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904893 vs KLHDC2 — GBM

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