Negative regulation of receptor signaling pathway via STAT

Across TCGA cell cohorts, RNA activity of the Negative regulation of receptor signaling pathway via STAT pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SOCS3, C11orf68, and SH2B3, each associated with the pathway in up to 15 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of receptor signaling pathway via STAT activity versus SOCS3 in BONE (Pearson r = 0.55).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	SOCS3 →	+2.224	+0.093	<.001	.003	3	15
URINARY_TRACT	C11orf68 →	+1.632	+0.144	<.001	<.001	3	14
LUNG_NSCLC_LUSC	SH2B3 →	+1.895	+0.137	<.001	<.001	3	13
LUNG_NSCLC_LUSC	ELK3 →	+1.595	+0.130	<.001	<.001	3	12
BONE	FOSL1 →	+3.519	+0.097	<.001	.001	3	12
LUNG_NSCLC_LUSC	SMURF2 →	+1.720	+0.110	.001	.004	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904893 vs SOCS3 — BONE

Explore this scatter interactively →