Regulation of excitatory synapse assembly

Across TCGA patient cohorts, RNA activity of the Regulation of excitatory synapse assembly pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PTPN13_S1029, PTPN13, and PTPN13_S969, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of excitatory synapse assembly activity versus PTPN13_S1029 in LUAD (Pearson r = 0.62).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	PTPN13_S1029 →	+1.206	+1.165	<.001	<.001	3	4
LUAD	PTPN13 →	+0.776	+1.169	<.001	<.001	3	4
LUAD	PTPN13_S969 →	+1.165	+1.059	<.001	<.001	3	4
LUAD	SRSF10_S160 →	-1.000	-1.377	<.001	<.001	3	3
BRCA	CHAF1B_S429 →	-0.805	-0.953	<.001	.004	2	4
LUAD	CTNNB1_S552 →	+0.411	+0.883	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904889 vs PTPN13_S1029 — LUAD

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