Regulation of excitatory synapse assembly

Across TCGA cell cohorts, RNA activity of the Regulation of excitatory synapse assembly pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GEN1, DSPP, and RAB10, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of excitatory synapse assembly activity versus GEN1 in OESOPHAGUS (Pearson r = 0.46).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	GEN1 →	+1.228	+0.363	.008	.004	3	4
LUNG_SCLC	DSPP →	+0.068	+1.096	.007	.003	3	3
LUNG_SCLC	RAB10 →	-0.571	-0.402	.003	<.001	2	4
LARGE_INTESTINE	PRPH →	+0.355	+0.741	.002	.005	3	3
SKIN	IL1RAP →	+1.660	+0.890	.002	.006	3	3
OVARY	DCAF4L1 →	+0.290	+0.329	.007	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904889 vs GEN1 — OESOPHAGUS

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