Negative regulation of calcium ion transmembrane transport via high voltage-gated calcium channel

Across TCGA patient cohorts, RNA activity of the Negative regulation of calcium ion transmembrane transport via high voltage-gated calcium channel pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are BIN1, BIN1_S331, and PCOLCE, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of calcium ion transmembrane transport via high voltage-gated calcium channel activity versus BIN1 in HNSC (Pearson r = 0.46).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	BIN1 →	+0.896	+0.080	<.001	<.001	3	7
HNSC	BIN1_S331 →	+0.836	+0.083	<.001	<.001	3	6
UCEC	PCOLCE →	-0.422	-0.067	.007	.003	3	6
CCRCC	VCL_S566 →	-1.403	-0.072	.001	.005	2	6
UCEC	VCL_S346 →	-0.495	-0.081	<.001	<.001	3	5
UCEC	AEBP1 →	-0.477	-0.082	.004	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904878 vs BIN1 — HNSC

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