Negative regulation of calcium ion transmembrane transport via high voltage-gated calcium channel

Across TCGA patient cohorts, RNA activity of the Negative regulation of calcium ion transmembrane transport via high voltage-gated calcium channel pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RRAD_S39, THOC1, and SHTN1_S494, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of calcium ion transmembrane transport via high voltage-gated calcium channel activity versus RRAD_S39 in BRCA (Pearson r = 0.16).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RRAD_S39 →	+0.796	+0.703	<.001	<.001	3	3
GBM	THOC1 →	-0.321	-0.444	<.001	.002	3	3
OV	SHTN1_S494 →	+1.965	+0.446	<.001	.001	3	3
UCEC	DACT3_S165 →	+1.016	+0.202	<.001	.001	3	3
GBM	ARHGAP30_S327 →	+0.753	+0.769	<.001	.002	3	3
LSCC	ARHGEF17_S723 →	+0.584	+1.017	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904878 vs RRAD_S39 — BRCA

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