Positive regulation of telomerase RNA localization to Cajal body

Across TCGA patient cohorts, RNA activity of the Positive regulation of telomerase RNA localization to Cajal body pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CSE1L, MRTO4, and RRP36_S73, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of telomerase RNA localization to Cajal body activity versus CSE1L in LSCC (Pearson r = 0.38).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	CSE1L →	+0.356	+0.051	<.001	<.001	3	9
BRCA	MRTO4 →	+0.435	+0.056	<.001	<.001	3	9
LUAD	RRP36_S73 →	+1.014	+0.065	<.001	<.001	3	8
UCEC	WDR43 →	+0.376	+0.082	<.001	<.001	3	8
LSCC	WDR75 →	+0.309	+0.061	<.001	<.001	3	8
LUAD	BRIX1 →	+0.382	+0.048	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904874 vs CSE1L — LSCC

Explore this scatter interactively →