Positive regulation of telomerase RNA localization to Cajal body

Across TCGA patient cohorts, RNA activity of the Positive regulation of telomerase RNA localization to Cajal body pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BCL2A1, SESTD1, and GK, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of telomerase RNA localization to Cajal body activity versus BCL2A1 in COAD (Pearson r = -0.25).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	BCL2A1 →	-1.365	-0.152	<.001	<.001	3	4
OV	SESTD1 →	-0.672	-0.088	<.001	.001	3	4
HNSC	GK →	-0.691	-0.113	.001	<.001	3	4
BRCA	CD300E →	-0.811	-0.112	.002	.007	3	4
OV	LOX →	-1.228	-0.092	.001	.006	3	4
GBM	ADM →	-1.173	-0.129	.005	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904874 vs BCL2A1 — COAD

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