Positive regulation of telomerase RNA localization to Cajal body

Across TCGA cell cohorts, RNA activity of the Positive regulation of telomerase RNA localization to Cajal body pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CCNG2, NOB1, and HSPD1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of telomerase RNA localization to Cajal body activity versus CCNG2 in STOMACH (Pearson r = -0.39).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	CCNG2 →	-1.261	-0.120	.009	.005	3	5
STOMACH	NOB1 →	+0.912	+0.123	<.001	.005	3	5
PANCREAS	HSPD1 →	+1.083	+0.265	<.001	.002	3	5
STOMACH	MAIP1 →	+0.765	+0.181	<.001	.002	3	5
STOMACH	H2BC21 →	-1.700	-0.181	.003	.008	3	5
KIDNEY	H2AC6 →	-2.220	-0.092	.008	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904874 vs CCNG2 — STOMACH

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