Positive regulation of telomerase RNA localization to Cajal body

pathway activity — cross-omics
GO:1904874Cross-omicsPROTEIN-MS → PROTEIN-MSCellPairwise association · TCGA cohorts

Across TCGA cell cohorts, RNA activity of the Positive regulation of telomerase RNA localization to Cajal body pathway is significantly associated with the protein abundance of multiple proteins, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are HAS1, CCT4, and TCP1, each associated with the pathway in up to 18 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of telomerase RNA localization to Cajal body activity versus HAS1 in PANCREAS (Pearson r = 0.85).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
PANCREASHAS1 →+2.632+0.405<.001.001318
PANCREASCCT4 →+2.564+0.428<.001<.001318
URINARY_TRACTTCP1 →+2.128+0.330<.001<.001318
URINARY_TRACTCCT6B →+2.376+0.330<.001<.001318
PANCREASCCT7 →+2.487+0.429<.001<.001318
PANCREASCCT6A →+2.357+0.437<.001<.001318
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904874 vs HAS1 — PANCREAS

Per-sample scatter of Positive regulation of telomerase RNA localization to Cajal body activity vs HAS1 in PANCREAS.

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Exploration