Excitatory synapse assembly

Across TCGA patient cohorts, RNA activity of the Excitatory synapse assembly pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are VSIG2, MAPK10, and HMMR, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Excitatory synapse assembly activity versus VSIG2 in LUAD (Pearson r = -0.07).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	VSIG2 →	+0.886	+0.598	.002	<.001	3	6
LUAD	MAPK10 →	+1.041	+0.933	<.001	<.001	3	5
LSCC	HMMR →	-0.898	-0.388	<.001	.003	3	5
BRCA	FEZ1 →	+0.537	+0.221	<.001	<.001	3	5
CCRCC	NOVA2 →	+0.641	+0.628	<.001	<.001	3	5
CCRCC	RASIP1 →	+0.822	+0.476	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904861 vs VSIG2 — LUAD

Explore this scatter interactively →