Excitatory synapse assembly

Across TCGA cell cohorts, RNA activity of the Excitatory synapse assembly pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KLHDC3, OBSCN, and TST, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, KLHDC3 grouped by Excitatory synapse assembly-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	KLHDC3 →	+0.636	+1.091	.002	.002	3	5
BREAST	OBSCN →	+1.377	+0.752	.002	.009	3	4
BONE	TST →	-1.644	-1.464	.006	.009	3	4
LUNG_SCLC	TRNP1 →	-1.603	-1.288	<.001	.001	3	4
BLOOD_Leukemia	SFPQ →	+0.679	+1.019	.002	.008	3	4
BLOOD_Leukemia	PRDX1 →	+1.729	+1.049	<.001	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

KLHDC3 by Excitatory synapse assembly activity — BLOOD_Leukemia

Explore this box plot interactively →