Excitatory synapse assembly

Across TCGA cell cohorts, RNA activity of the Excitatory synapse assembly pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RPL6, SSH3, and SEMA4A, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Excitatory synapse assembly activity versus RPL6 in LIVER (Pearson r = -0.92).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	RPL6 →	-1.125	-1.428	.007	<.001	3	5
PANCREAS	SSH3 →	+1.963	+1.845	.006	<.001	3	5
BREAST	SEMA4A →	+2.992	+1.517	<.001	<.001	3	4
SKIN	UBL4A →	-0.437	-1.418	.002	.004	3	4
SKIN	PPIF →	-1.243	-1.466	.001	<.001	3	4
LIVER	CISD1 →	-0.915	-1.348	<.001	.005	1	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904861 vs RPL6 — LIVER

Explore this scatter interactively →