Positive regulation of establishment of protein localization to telomere

Across TCGA patient cohorts, RNA activity of the Positive regulation of establishment of protein localization to telomere pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TPX2, MCM3, and HEATR1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of establishment of protein localization to telomere activity versus TPX2 in LUAD (Pearson r = -0.01).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	TPX2 →	+0.727	+0.057	<.001	<.001	3	8
GBM	MCM3 →	+0.853	+0.046	<.001	.001	3	8
UCEC	HEATR1 →	+0.402	+0.092	<.001	<.001	3	8
LUAD	PHF6 →	+0.341	+0.061	<.001	<.001	3	8
HNSC	RIF1 →	+0.362	+0.099	<.001	.002	3	7
GBM	STAG2 →	+0.285	+0.042	.002	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904851 vs TPX2 — LUAD

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