Positive regulation of establishment of protein localization to telomere

Across TCGA patient cohorts, RNA activity of the Positive regulation of establishment of protein localization to telomere pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SKAP2, EIF5B, and ARPC2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of establishment of protein localization to telomere activity versus SKAP2 in CCRCC (Pearson r = -0.10).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	SKAP2 →	-0.301	-0.082	.001	.008	3	5
CCRCC	EIF5B →	-0.357	-0.120	.002	.007	3	4
COAD	ARPC2 →	-0.375	-0.104	.002	<.001	3	4
COAD	DENND4A →	-0.356	-0.135	<.001	<.001	3	4
COAD	MCUB →	-0.562	-0.084	<.001	.001	3	4
OV	GDAP2 →	-0.347	-0.084	<.001	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904851 vs SKAP2 — CCRCC

Explore this scatter interactively →