Positive regulation of establishment of protein localization to telomere

Across TCGA cell cohorts, RNA activity of the Positive regulation of establishment of protein localization to telomere pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are WRAP53, CCT6A, and TRAPPC1, each associated with the pathway in up to 16 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of establishment of protein localization to telomere activity versus WRAP53 in LUNG_NSCLC_LUSC (Pearson r = -0.61).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	WRAP53 →	-0.955	-0.049	<.001	<.001	3	16
SKIN	CCT6A →	+0.842	+0.052	<.001	<.001	3	10
LUNG_NSCLC_LUSC	TRAPPC1 →	-0.953	-0.057	.003	.004	3	10
LARGE_INTESTINE	NAA38 →	-1.144	-0.050	<.001	<.001	3	10
LUNG_NSCLC_LUAD	IFNGR1 →	+1.157	+0.057	<.001	<.001	3	9
STOMACH	RANGRF →	-1.003	-0.048	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904851 vs WRAP53 — LUNG_NSCLC_LUSC

Explore this scatter interactively →