Positive regulation of establishment of protein localization to telomere

Across TCGA cell cohorts, RNA activity of the Positive regulation of establishment of protein localization to telomere pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IER5L, PIGA, and PRDM15, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of establishment of protein localization to telomere activity versus IER5L in BONE (Pearson r = -0.93).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	IER5L →	-1.484	-0.144	.008	.001	3	4
CNS	PIGA →	-0.733	-0.131	.008	.004	3	4
BREAST	PRDM15 →	-0.598	-0.085	.003	.005	3	3
BONE	NIN →	-2.333	-0.183	.006	.001	3	3
BLOOD_Leukemia	SENP3 →	-0.710	-0.080	<.001	.004	3	3
BONE	NEMF →	-1.063	-0.183	.003	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904851 vs IER5L — BONE

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