Regulation of cell chemotaxis to fibroblast growth factor

Across TCGA patient cohorts, RNA activity of the Regulation of cell chemotaxis to fibroblast growth factor pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ILK, RENBP, and FGF2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of cell chemotaxis to fibroblast growth factor activity versus ILK in COAD (Pearson r = 0.26).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	ILK →	+0.407	+0.059	<.001	<.001	3	6
COAD	RENBP →	+0.364	+0.071	<.001	<.001	3	6
CCRCC	FGF2 →	+0.505	+0.083	.001	<.001	3	6
BRCA	ARSB →	+0.300	+0.047	<.001	<.001	3	5
LSCC	SYNPO →	+0.293	+0.085	.002	.002	3	5
BRCA	TLN1_S1201 →	+0.791	+0.064	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904847 vs ILK — COAD

Explore this scatter interactively →