Regulation of cell chemotaxis to fibroblast growth factor

Across TCGA patient cohorts, RNA activity of the Regulation of cell chemotaxis to fibroblast growth factor pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are WFDC1, LTBP2, and FBLN5, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of cell chemotaxis to fibroblast growth factor activity versus WFDC1 in CCRCC (Pearson r = 0.40).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	WFDC1 →	+0.521	+0.562	<.001	<.001	3	6
BRCA	LTBP2 →	+0.962	+0.759	<.001	<.001	3	6
CCRCC	FBLN5 →	+1.135	+0.610	<.001	<.001	3	6
LUAD	MFAP4 →	+0.909	+0.762	.001	<.001	3	6
BRCA	CORO2B →	+0.446	+0.623	.008	.001	3	5
CCRCC	C7 →	+2.226	+0.683	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904847 vs WFDC1 — CCRCC

Explore this scatter interactively →