Regulation of cell chemotaxis to fibroblast growth factor

Across TCGA cell cohorts, RNA activity of the Regulation of cell chemotaxis to fibroblast growth factor pathway is significantly associated with the shRNA dependency of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are STRN, PRDX1, and PPP3R2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, STRN grouped by Regulation of cell chemotaxis to fibroblast growth factor-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	STRN →	-0.261	-1.292	.006	.009	3	5
LUNG_SCLC	PRDX1 →	+0.307	+0.836	<.001	.006	3	5
SOFT_TISSUE	PPP3R2 →	+0.344	+1.670	.004	.002	3	4
BREAST	BRMS1 →	+0.140	+0.967	<.001	<.001	3	4
LIVER	CLCN3 →	+0.231	+1.454	.006	.003	3	4
PANCREAS	USP17L1 →	+0.423	+1.779	.002	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

STRN by Regulation of cell chemotaxis to fibroblast growth factor activity — SOFT_TISSUE

Explore this box plot interactively →