Purine nucleobase transmembrane transport

Across TCGA patient cohorts, RNA activity of the Purine nucleobase transmembrane transport pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are FCN1, ITGAM, and ITGB2, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Purine nucleobase transmembrane transport activity versus FCN1 in GBM (Pearson r = 0.43).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	FCN1 →	+1.566	+0.091	<.001	<.001	3	9
UCEC	ITGAM →	+0.693	+0.109	<.001	<.001	3	9
PDAC	ITGB2 →	+0.706	+0.069	<.001	<.001	3	9
UCEC	MNDA →	+0.785	+0.105	<.001	<.001	3	9
UCEC	SKAP2 →	+0.640	+0.109	<.001	<.001	3	8
PDAC	CYBB →	+0.714	+0.056	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904823 vs FCN1 — GBM

Explore this scatter interactively →