Purine nucleobase transmembrane transport

Across TCGA patient cohorts, RNA activity of the Purine nucleobase transmembrane transport pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FAM20A, INSYN2B, and APOC1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Purine nucleobase transmembrane transport activity versus FAM20A in PDAC (Pearson r = 0.34).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	FAM20A →	+0.489	+0.268	<.001	.008	3	4
LSCC	INSYN2B →	+0.659	+0.409	<.001	.004	3	4
BRCA	APOC1 →	+0.933	+0.361	.007	.007	2	4
OV	MGST3 →	-0.332	-0.812	.009	<.001	3	3
LUAD	KIF26B →	-0.750	-0.624	<.001	.001	3	3
UCEC	BIK →	-1.090	-0.262	<.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904823 vs FAM20A — PDAC

Explore this scatter interactively →