Purine nucleobase transmembrane transport

Across TCGA patient cohorts, RNA activity of the Purine nucleobase transmembrane transport pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SLC29A3_S23, SLC43A3, and TYROBP, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Purine nucleobase transmembrane transport activity versus SLC29A3_S23 in LSCC (Pearson r = 0.32).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SLC29A3_S23 →	+1.407	+0.495	<.001	.002	3	6
UCEC	SLC43A3 →	+1.380	+0.351	<.001	<.001	3	5
UCEC	TYROBP →	+0.896	+0.338	<.001	<.001	3	4
UCEC	RAB32 →	+0.458	+0.443	<.001	<.001	2	5
UCEC	CYBA →	+0.818	+0.331	<.001	<.001	3	4
UCEC	SLC43A2_S274 →	+0.718	+0.442	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904823 vs SLC29A3_S23 — LSCC

Explore this scatter interactively →