Purine nucleobase transmembrane transport

Across TCGA cell cohorts, RNA activity of the Purine nucleobase transmembrane transport pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are USPL1, FBRS, and DPF2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, USPL1 grouped by Purine nucleobase transmembrane transport-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	USPL1 →	+0.518	+1.106	.002	.002	3	4
CNS	FBRS →	-0.611	-0.708	.005	.006	3	4
BLOOD_Leukemia	DPF2 →	-0.593	-1.178	.002	.006	3	4
LARGE_INTESTINE	FAM167B →	-0.371	-1.244	.001	.002	3	4
BLOOD_Myeloma	ING1 →	-0.729	-1.913	.004	<.001	3	3
BLOOD_Myeloma	UPF3A →	-1.220	-2.048	.009	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

USPL1 by Purine nucleobase transmembrane transport activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →