"Regulation of protein localization to chromosome, telomeric region"

Across TCGA cell cohorts, RNA activity of the "Regulation of protein localization to chromosome, telomeric region" pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PML, APOL1, and IFI44, each associated with the pathway in up to 11 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Regulation of protein localization to chromosome, telomeric region" activity versus PML in PANCREAS (Pearson r = 0.62).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	PML →	+1.112	+0.216	.004	<.001	2	11
BLOOD_Lymphoma	APOL1 →	+3.517	+0.199	<.001	<.001	3	9
UPPER_AERODIGESTIVE_TRACT	IFI44 →	+3.746	+0.246	<.001	.003	2	10
KIDNEY	NDUFA4 →	-1.032	-0.154	.004	.004	3	9
OVARY	MX1 →	+2.570	+0.223	.002	.007	3	8
LIVER	LAMB3 →	+4.092	+0.316	<.001	.008	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904814 vs PML — PANCREAS

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