Positive regulation of protein localization to centrosome

Across TCGA patient cohorts, RNA activity of the Positive regulation of protein localization to centrosome pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PAFAH1B3, SERPINB1, and BICD1_S548, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of protein localization to centrosome activity versus PAFAH1B3 in GBM (Pearson r = 0.35).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	PAFAH1B3 →	+0.342	+0.062	.006	.002	3	6
HNSC	SERPINB1 →	-0.669	-0.087	<.001	<.001	3	5
BRCA	BICD1_S548 →	+0.662	+0.049	<.001	<.001	3	5
HNSC	EPS8L2_S240 →	-0.661	-0.074	.004	.004	2	6
HNSC	PDZK1IP1_S89 →	-0.820	-0.086	<.001	<.001	3	5
BRCA	NAE1 →	+0.223	+0.029	<.001	.005	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904781 vs PAFAH1B3 — GBM

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