Positive regulation of protein localization to centrosome

Across TCGA patient cohorts, RNA activity of the Positive regulation of protein localization to centrosome pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are APC_S2449, APC, and APC_S1042, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of protein localization to centrosome activity versus APC_S2449 in OV (Pearson r = 0.52).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	APC_S2449 →	+1.110	+0.323	<.001	<.001	3	6
GBM	APC →	+0.292	+0.546	<.001	<.001	3	4
GBM	APC_S1042 →	+0.799	+1.036	<.001	<.001	3	4
BRCA	PRKD2_S710 →	-0.785	-0.290	<.001	<.001	3	3
PDAC	TBC1D23_S466 →	+0.750	+0.557	<.001	<.001	3	3
CCRCC	ELOF1 →	+0.601	+0.524	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904781 vs APC_S2449 — OV

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