Positive regulation of protein localization to centrosome

Across TCGA cell cohorts, RNA activity of the Positive regulation of protein localization to centrosome pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are APC, BICD1, and DMWD, each associated with the pathway in up to 17 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of protein localization to centrosome activity versus APC in LUNG_NSCLC_LUSC (Pearson r = 0.56).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	APC →	+1.208	+0.085	<.001	.005	3	17
BREAST	BICD1 →	+1.501	+0.090	<.001	<.001	3	16
BLOOD_Leukemia	DMWD →	+1.180	+0.065	<.001	<.001	3	15
STOMACH	CIC →	+1.320	+0.130	<.001	<.001	3	14
STOMACH	MARK4 →	+1.373	+0.152	<.001	<.001	3	14
LARGE_INTESTINE	PKD1 →	+1.555	+0.075	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904781 vs APC — LUNG_NSCLC_LUSC

Explore this scatter interactively →