Positive regulation of protein localization to centrosome

Across TCGA cell cohorts, RNA activity of the Positive regulation of protein localization to centrosome pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FAM72A, KLHL24, and ERP44, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of protein localization to centrosome activity versus FAM72A in BLOOD_Leukemia (Pearson r = 0.71).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	FAM72A →	+1.077	+1.225	.001	<.001	3	4
LUNG_SCLC	KLHL24 →	+1.432	+1.140	<.001	.004	3	4
STOMACH	ERP44 →	+0.429	+1.528	.008	<.001	3	4
BLOOD_Leukemia	SRP9 →	+1.181	+1.482	.001	<.001	3	3
BLOOD_Myeloma	ZUP1 →	+0.769	+1.513	.007	.004	3	3
BLOOD_Leukemia	IDH3A →	+1.315	+1.229	.005	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904781 vs FAM72A — BLOOD_Leukemia

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